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Cell Mol Life Sci 68:22012213

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SOD2 deficiency resulted in mitochondrial dysfunction and cellular senescence in the epidermis, as well as epidermal thinning, a known feature of aging skin. [8] What this means is you get an increased thickness of the stratum corneum and thinning in the epidermis

Research Evidence: Studies, including a randomized controlled trial published in Clinical, Cosmetic and Investigational Dermatology, have shown that oral glutathione (500 mg daily) taken over 8-12 weeks can result in noticeable improvement in melasma severity compared to placebo